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KMID : 0811720150190010029
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Korean Journal of Physiology & Pharmacology
2015 Volume.19 No. 1 p.29 ~ p.34
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ERK Activation by Fucoidan Leads to Inhibition of Melanogenesis in Mel-Ab Cells
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Song Yu-Seok
Marie Carmel Balcos
Yun Hye-Young
Baek Kwang-Jin
Kwon Nyoun-Soo
Kim Myo-Kyoung
Kim Dong-Seok
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Abstract
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Fucoidan, a fucose-rich sulfated polysaccharide derived from brown seaweed in the class Phaeo-phyceae, has been widely studied for its possible health benefits. However, the potential of fucoidan as a possible treatment for hyperpigmentation is not fully understood. This study investigated the effects of fucoidan on melanogenesis and related signaling pathways using Mel-Ab cells. Fucoidan significantly decreased melanin content. While fucoidan treatment decreased tyrosinase activity, it did not do so directly. Western blot analysis indicated that fucoidan downregulated microphthalmia- associated transcription factor and reduced tyrosinase protein expression. Further investigation showed that fucoidan activated the extracellular signal-regulated kinase (ERK) pathway, suggesting a possible mechanism for the inhibition of melanin synthesis. Treatment with PD98059, a specific ERK inhibitor, resulted in the recovery of melanin production. Taken together, these findings suggest that fucoidan inhibits melanogenesis via ERK phosphorylation.
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KEYWORD
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ERK, Fucoidan, Melanogenesis, MITF, Tyrosinase
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